A pilot prospective study to evaluate whether the bladder morphology in cystography and/or urodynamic may help predict the response to botulinum toxin a injection in neurogenic bladder refractory to anticholinergics

This study aimed to see if bladder shape and function tests could predict how well people with nerve-related bladder problems respond to Botox injections. The goal was to find ways to better select patients who would benefit most from this treatment. Researchers looked at bladder images (cystography) and bladder function tests (urodynamics) in patients with neurogenic detrusor overactivity (NDO) who weren't helped by anticholinergic medications. They then looked to see if certain features in these tests could predict who responded well to Botox injections. The study found that some bladder function test results were different between those who responded well to Botox and those who didn't. However, bladder shape and the presence of pouches (diverticula) did not predict who would respond to Botox injections.

• 1
  Cystography parameters (bladder shape, capacity, diverticula) did not significantly predict response to BTX-A injections.
• 2
  Patients who responded successfully to BTX-A had greater maximum cystometric capacity (MCC), higher reflex volume (RV), and greater compliance before treatment.
• 3
  Maximum detrusor pressure (MDP) was not significantly different between responders and non-responders.