Activating effective functional hand movements in individuals with complete tetraplegia through neural stimulation

Scientific Reports, 2022 · DOI: 10.1038/s41598-022-19906-x · Published: October 6, 2022

Simple Explanation

This research introduces a neuroprosthetic solution designed to restore hand motor function in individuals with complete tetraplegia. The system uses electrical stimulation of the radial and median nerves via epineural electrodes to enable functional hand movements. Two participants with complete tetraplegia were able to trigger hand movements using an intuitive interface, performing tasks like holding a can and drinking through a straw.

Study Duration

28 days

Participants

Two male participants with complete C4 AIS A tetraplegia

Evidence Level

Not specified

Key Findings

1
Selective stimulation of nerve fascicles induced functional and powerful grasping movements that remained stable over 28 days of implantation.
2
Participants could trigger movements of their paralyzed limbs using an intuitive interface controlled by voluntary actions.
3
The participants were able to perform useful functional movements, such as holding a can and drinking through a straw.

Research Summary

The study demonstrates a neuroprosthetic solution using electrical stimulation of the radial and median nerves to restore hand motor function in individuals with complete tetraplegia. Two participants with complete tetraplegia showed stable grasping movements over 28 days, triggered by an intuitive interface. The participants could perform functional tasks like holding a can and drinking through a straw, highlighting the potential for improved autonomy.

Practical Implications

Restoration of Hand Function

The neuroprosthetic solution offers a potential method for restoring hand motor function in individuals with complete tetraplegia, improving their autonomy and quality of life.

Selective Neural Stimulation

The use of selective neural stimulation with multicontact epineural electrodes demonstrates a more efficient way of tuning neuroprostheses compared to traditional muscle-by-muscle tuning.

Intuitive User Interface

The intuitive user interface allows patients to control the activation of movements in their paralyzed limbs using voluntary actions, making the system more user-friendly and adaptable.

Study Limitations

1
Surface EMG includes crosstalk between muscles, requiring further confirmation with wired or high-density EMG.
2
Movements were insufficient to provide stable grasping without a wrist brace due to the need for wrist extension.
3
All-or-nothing stimulation paradigms were used without the ability to modulate stimulation during execution.

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