Bacterial-Mediated Tumor Therapy: Old Treatment in a New Context

Bacteria-mediated antitumor therapy provides new options to address challenges in cancer treatment by destroying tumor cells from the inside and inducing antitumor immune responses. Bacteria and their accessory products can be reprogrammed to produce and deliver antitumor agents according to clinical needs. BMAT has many advantages including tumor targeting, intratumoral penetration, tumor colonization, and bacterial cytotoxicity for tumor killing.

• 1
  Certain types of tumor have their own unique microbial composition, which has an important role in the survival of cancer patients.
• 2
  Engineered bacteria can strictly control the expression of related genes, which is crucial for managing the time and place of drug production.
• 3
  Bacterial OMVs have been extensively studied as delivery vehicles or vaccines due to their ability to stimulate immune maturation and initiate inflammation in a controllable manner.