Bladder response to acute sacral neuromodulation while treating rats in different phases of complete spinal cord injury: a preliminary study

This study explores sacral neuromodulation (SNM) as a potential non-destructive treatment for bladder dysfunction in spinal cord injury (SCI) patients. The research investigates how the timing of SNM treatment affects bladder response in rats with complete SCI, aiming to provide insights for optimizing the use of this technique. The study analyzes cystometric parameters in rats before and after SNM treatment during different phases of SCI, focusing on contraction time, duration, and bladder pressure.

• 1
  SNM's effectiveness varies depending on the phase of SCI: early phase (less than two weeks post-spinalization) showed minimal increases in contraction time and duration.
• 2
  Rats treated two to four weeks post-spinalization showed substantial increases in contraction time and duration after SNM, with average value changes exceeding 90%.
• 3
  Rats treated more than five weeks post-spinalization showed increased contraction time and duration after SNM, but the magnitude of changes was less than 30%.