Cell cycle and complement inhibitors may be specific for treatment of spinal cord injury in aged and young mice: transcriptomic analyses

This study examined gene expression profiles in young and aged mice after spinal cord injury to understand age-specific mechanisms. The researchers identified differentially expressed genes (DEGs) specific to aged and young mice, suggesting different treatment approaches may be needed. The study suggests that cell cycle inhibitors may be specific treatments for spinal cord injury in aged mice, while complement inhibitors may be specific for young mice.

• 1
  Aged mice showed a higher number of differentially expressed genes (DEGs) after SCI compared to young mice.
• 2
  960 shared DEGs between young and aged injured groups suggests these genes are important for development of SCI.
• 3
  Functional enrichment analysis indicates unique genes for aged injured groups were involved in the cell cycle, while young injured groups were involved in complement activation.