Clinical and Neurophysiologic Assessment of Strength and Spasticity During Intrathecal Baclofen Titration in Incomplete Spinal Cord Injury: Single-Subject Design

This study looks at how different doses of baclofen, given either as a pill or directly into the spinal fluid, affect muscle strength and stiffness in someone with a spinal cord injury. The researchers used both regular clinical tests and special nerve tests to measure these effects. The goal was to see if controlling stiffness with baclofen could be done without making the person weaker, and to check if the clinical and nerve tests gave similar results.

• 1
  Spasticity and strength changed as the baclofen dose was adjusted.
• 2
  Nerve tests showed big changes in reflexes with baclofen, while muscle strength changes were smaller.
• 3
  The nerve tests mostly matched what the clinical tests showed.