Spinal Cord, 2016 · DOI: 10.1038/sc.2015.143 · Published: August 11, 2015
This study investigated whether injecting botulinum toxin A (BTX-A) into both the detrusor muscle and the trigone area of the bladder is more effective than injecting it only into the detrusor muscle for treating urinary incontinence caused by neurogenic detrusor overactivity (NDO). The study compared two groups of patients with spinal cord injuries and urinary incontinence due to NDO: one group received BTX-A injections in the detrusor muscle excluding the trigone, and the other group received injections in both the detrusor muscle and the trigone. The results showed that the group receiving injections in both areas experienced greater improvements in incontinence-related quality of life, fewer incontinence episodes, increased voiding volume, and reduced bladder pressure.
Combined detrusor-trigone BTX-A injections may be considered as a more effective treatment option for patients with NDO and urinary incontinence compared to detrusor-only injections.
Patients may experience improved quality of life, reduced incontinence episodes, and better bladder control with the combined injection approach.
The study supports the safety of intratrigonal BTX-A injections, as no cases of VUR were observed.