Combined topical and systemic administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration

Stem Cell Research & Therapy, 2021 · DOI: https://doi.org/10.1186/s13287-021-02287-9 · Published: May 14, 2021

Dermatology Regenerative Medicine & Stem Cells

Simple Explanation

This study investigates the potential of human adipose-derived mesenchymal stem cells (hADSC) and their exosomes (hADSC-Exo) in promoting cutaneous wound healing. The research found that combining topical application of hADSC-Exo with systemic administration of hADSC/hADSC-Exo significantly enhanced wound healing in mice. The findings suggest that hADSC-Exo can be used as a cell-free therapy for treating cutaneous wounds, potentially offering a simple and effective clinical treatment for both acute and chronic wounds.

Study Duration

Not specified

Participants

Male ICR mice (7 weeks old)

Evidence Level

Not specified

Key Findings

1
Combined application of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration promoted wound healing and accelerated re-epithelialization.
2
Topical application of hADSC-Exo or systemic administration with hADSC/hADSC-Exo stimulated cell proliferation and inhibited cell apoptosis and inflammation.
3
hADSC-Exo-sm promoted collagen synthesis and skin barrier repair in vivo, with increased expression of Filaggrin, Loricrin, and AQP3.

Research Summary

This study explored the therapeutic effects of hADSC and hADSC-Exo on wound healing and cutaneous regeneration in a mouse model. The findings demonstrate that combined treatment with hADSC and hADSC-Exo significantly promotes cutaneous wound healing, collagen synthesis, vascularization, and skin barrier repair. The research suggests that hADSC-Exo can be used as an effective cell-free therapy for skin wound repair, especially for extensive burns, trauma, or ulcers.

Practical Implications

Clinical Treatment

Combined administration of hADSC/hADSC-Exo may offer a novel therapeutic approach for cutaneous wound healing and reducing scar formation.

Cell-Free Therapy

Smearing of hADSC-Exo presents a feasible cell-free therapy option for treating cutaneous wounds, avoiding risks associated with cell-based therapies.

Drug Development

hADSC-Exo can be explored as a potential drug for promoting skin elasticity and barrier integrity, especially in cases of extensive burns, trauma, or ulcers.

Study Limitations

1
The study was conducted on a mouse model, and results may not directly translate to humans.
2
Further research is needed to understand the precise mechanisms of action of hADSC-Exo in wound healing.
3
Long-term effects and potential side effects of hADSC/hADSC-Exo treatment were not evaluated.

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