Comparative transcriptomics of limb regeneration: Identification of conserved expression changes among three species of Ambystoma

This study explores the genetic basis of limb regeneration in salamanders by comparing gene expression in three different species after limb amputation. The researchers identified a set of genes that are commonly expressed across all three species during the early stages of limb regeneration, suggesting these genes play a crucial role in the regeneration process. The findings provide a valuable resource for identifying key factors that control wound healing and regeneration, potentially leading to new strategies for inducing regeneration in non-regenerative organisms.

• 1
  Identified 405 non-redundant genes that were commonly, differentially expressed 24 h post amputation across three Ambystoma species.
• 2
  Upregulated genes are predicted to function in wound healing and developmental processes.
• 3
  Downregulated genes are typically expressed in muscle.