Cysteine and glycine-rich protein 1 is involved in spinal cord regeneration in adult zebrafish

Adult zebrafish can regrow axons and recover movement after spinal cord injury, unlike mammals. This ability is due to neurons re-expressing growth-associated genes. The study found that cysteine and glycine-rich protein 1 (CRP1) is upregulated after spinal cord injury. This upregulation occurs in neurons during axon growth. Knocking down CRP1 impaired axon regeneration and locomotor recovery. This shows CRP1 is important for the innate regeneration capability of injured neurons.

• 1
  CRP1 (csrp1a) is upregulated in neurons after spinal cord injury (SCI) in zebrafish. The upregulation occurs in regenerative nuclei like NMLF, IMRF, and SRF.
• 2
  The upregulation of csrp1a in regenerating nuclei starts at 3 days after SCI and continues up to 21 days post-injury.
• 3
  Knockdown of CRP1 impairs axon regeneration and locomotor recovery after spinal cord injury, demonstrating CRP1's importance for regeneration.