J Tissue Viability, 2010 · DOI: 10.1016/j.jtv.2009.11.009 · Published: May 1, 2010
This study proposes a new rat model for pressure ulcers (PU) and deep tissue injuries (DTI) that is more clinically relevant. It includes a chronic spinal cord injury (SCI) condition in the rat PU model. The model simulates the role of bony prominence in DTI formation by using an implant on the bone-tissue interface, making it more like the actual conditions in human patients. The findings confirm that chronic SCI and the simulated bony prominence significantly affect pressure-induced tissue injury in rats, suggesting the model can yield more clinically relevant findings.
The new rat model, incorporating SCI and bony prominence simulation, allows for more clinically relevant preclinical studies of pressure ulcer and deep tissue injury development.
By more accurately mimicking clinical conditions, the model can facilitate the development of targeted treatments for pressure ulcers in SCI patients.
The model provides a better tool to understand the mechanisms of deep tissue injury formation, particularly the role of bony prominences.