Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

This study uses metabolomics to find links between diet and cognitive decline. Researchers looked at blood samples from older adults over 12 years to see if certain metabolites (small molecules) were linked to cognitive decline. They found that some metabolites related to coffee, cocoa, and fish were associated with slower cognitive decline, while others related to citrus juice were linked to faster decline.

• 1
  A baseline serum signature of 22 metabolites was associated with subsequent cognitive decline.
• 2
  The signature included coffee metabolites, a citrus intake biomarker, a cocoa metabolite, and metabolites potentially from fish and wine.
• 3
  Adding these metabolites to a standard predictive model significantly improved its ability to predict cognitive decline.