Editorial: Advances in CNS Repair, Regeneration, and Neuroplasticity: From Basic Mechanisms to Therapeutic Strategies

This editorial discusses recent preclinical research advances in CNS repair, regeneration, and neuroplasticity, focusing on new molecular and cellular targets and effective therapeutic strategies. The Research Topic includes studies targeting multiple molecular and cellular components using several model systems, including traumatic brain injury (TBI), spinal cord injury (SCI), optic nerve crush (ONC), neurodegeneration, and in vitro cell cultures. Many articles focused on enhancing viability of neural cells and regeneration, reconnection, and plasticity of injured CNS neurons by targeting diverse CNS pathophysiology, including inflammatory cascades and regeneration failure of axotomized CNS axons.

• 1
  Identified druggable targets to intervene with secondary brain injuries like ischemia, hemorrhage, and mitochondrial dysfunction after TBI.
• 2
  Non-invasive respiratory treatments may enhance neuroplasticity and long-term recovery after cervical SCI, improving both respiratory and potentially locomotor neural networks.
• 3
  Combinatory manipulation of multiple crucial genes and pathways could stimulate long-distance axon regeneration in mice with ONC.