Editorial: (Osteo)Sarcopenia & sarcopenic obesity

Frontiers in Endocrinology, 2023 · DOI: 10.3389/fendo.2023.1270350 · Published: August 24, 2023

Simple Explanation

The editorial discusses the increasing prevalence of sarcopenia, osteosarcopenia, and sarcopenic obesity due to the aging global population and advancements in healthcare, emphasizing the need for strategies to manage these conditions. It highlights research exploring biomarkers for early sarcopenia detection, the association of sarcopenia with conditions like knee osteoarthritis and neurological disorders, and the impact of body composition on mortality. The editorial concludes by advocating for multidisciplinary approaches in managing sarcopenia-related conditions, including exercise, nutrition, and pharmacological interventions, to improve patient outcomes.

Study Duration

Not specified

Participants

Not specified

Evidence Level

Not specified

Key Findings

1
Fasting insulin combined with the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio are appropriate predictors of sarcopenia.
2
Higher AST/ALT and lower insulin*prealbumin product were associated with a higher prevalence of sarcopenia among elderly Chinese participants.
3
Severe osteoporosis increases the risk of appendicular lean mass loss and subsequent reduced lumbar spine bone mineral density.

Research Summary

The editorial emphasizes the increasing prevalence of sarcopenia, osteosarcopenia, and sarcopenic obesity due to the aging global population and advancements in healthcare. It highlights the importance of early diagnosis and screening tools, biomarker research, and the association of sarcopenia with various comorbidities. The editorial advocates for multidisciplinary approaches involving exercise, nutrition, and pharmacological interventions to manage sarcopenia-related conditions and improve patient outcomes.

Practical Implications

Early Detection of Sarcopenia

Using biomarkers like fasting insulin and AST/ALT ratio for early sarcopenia screening can enable timely interventions.

Personalized Rehabilitation Strategies

Tailoring interventions based on individual needs, including exercise, nutrition, and medication, can improve outcomes for those with osteosarcopenia and sarcopenic obesity.

Multidisciplinary Care

Collaboration among healthcare professionals is crucial for effectively managing the complexity of sarcopenia-related conditions.

Study Limitations

1
Limited generalizability of findings from specific populations (e.g., elderly Chinese participants).
2
Need for further research to establish versatile and user-friendly screening tools for sarcopenia.
3
Complexity of fully understanding and managing sarcopenia-related conditions remains challenging.

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