Effect of docosahexaenoic acid on the recovery of motor function in rats with spinal cord injury: a meta-analysis

Neural Regen Res, 2020 · DOI: 10.4103/1673-5374.266065 · Published: March 1, 2020

Spinal Cord Injury Nutrition & Dietetics Research Methodology & Design

Simple Explanation

This study investigates the effect of docosahexaenoic acid (DHA) on motor function recovery in rats with spinal cord injury (SCI). DHA is a type of omega-3 fatty acid, known for its potential benefits in nerve-related conditions. The study analyzes existing research to determine if DHA can improve motor function after SCI in rats, and if the method, timing, and dosage of DHA administration affect recovery. The research suggests that DHA can indeed promote motor functional recovery after SCI in rats, with intravenous or subcutaneous injections being more effective than oral administration.

Study Duration

Not specified

Participants

Laboratory rats

Evidence Level

Meta-analysis

Key Findings

1
The highest mean Basso, Beattie, and Bresnahan scale score occurred at 42 days after DHA treatment in spinal cord injury rats.
2
Improvement in the Basso, Beattie, and Bresnahan scale score was more significant in rats administered DHA intravenously and subcutaneously than in the groups administered DHA orally.
3
Intravenous injection of DHA at doses of 250 nmol/kg or 1000 nmol/kg significantly improved the Basso, Beattie, and Bresnahan scale score in rats and promoted the recovery of motor function.

Research Summary

This meta-analysis assesses the effect of DHA on motor function recovery in rat models of SCI, confirming that DHA administration significantly improved functional recuperation. The ability of DHA to promote motor function recovery was positively correlated with time during the first week after SCI, with intravenous and subcutaneous injections being more effective than oral administration. Intravenous injection of DHA at doses of 250 nmol/kg and 1000 nmol/kg showed similar effects on motor function recovery, suggesting a potential therapeutic benefit of DHA for SCI.

Practical Implications

Potential Therapeutic Strategy

DHA could be explored as a potential therapeutic agent for promoting motor function recovery after spinal cord injury.

Administration Method Matters

The method of DHA administration significantly impacts its effectiveness, with injections showing more promise than oral intake.

Dosage Considerations

Intravenous DHA injections at 250 nmol/kg or 1000 nmol/kg have similar effects; further research could refine optimal dosage strategies.

Study Limitations

1
The methodological quality of the included studies was generally low.
2
There is a shortage of original studies, potentially leading to publication bias.
3
There were too few related studies to draw unequivocal conclusions about the efficacy of different DHA doses and dosage forms.

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