Effect of kidney‑reinforcing and marrow‑beneficial Chinese medicine on bone metabolism‑related factors following spinal cord injury in rats

This study investigates the effect of Kidney Reinforcing and Marrow-Beneficial (KRMB) traditional Chinese medicine on osteoporosis (OP) resulting from spinal cord injury (SCI) in rats. Rat models of OP following SCI were surgically created, and the effects of KRMB on bone mineral density (BMD) and the expression of certain proteins were observed. The results suggest that KRMB may have a positive effect on secondary OP caused by SCI, potentially through its influence on bone metabolism-related factors.

• 1
  BMD expression in the SCI model group was significantly lower compared with the normal, sham + KRMB and normal + KRMB groups at 4, 6, 8 and 10 weeks.
• 2
  The level of serum BGP in the SCI model group was significantly higher compared with the normal, sham + KRMB and normal + KRMB groups at each time point, and lower than the SCI + KRMB group.
• 3
  Hepcidin mRNA expression in the rat livers in the normal, sham + KRMB and normal + KRMB group was significantly higher than that in the SCI + KRMB group and SCI model group at each time point.