Electroacupuncture facilitates the integration of a grafted TrkC-modified mesenchymal stem cell-derived neural network into transected spinal cord in rats via increasing neurotrophin-3

CNS Neuroscience & Therapeutics, 2021 · DOI: 10.1111/cns.13638 · Published: February 24, 2021

Spinal Cord Injury Neurology Regenerative Medicine & Stem Cells

Simple Explanation

This research investigates whether electroacupuncture (EA) can boost levels of a specific growth factor (NT-3) in injured spinal cords of rats. The study also examines if this increased NT-3 can help implanted, modified stem cells (TrkC-MSCs) survive, grow into nerve-like cells, and move into the damaged spinal cord. Finally, researchers checked if these cells could integrate into the spinal cord's existing network to improve movement after injury.

Study Duration

8 weeks

Participants

84 Sprague-Dawley rats

Evidence Level

Level 2: Experimental study in a rat model of spinal cord injury

Key Findings

1
Electroacupuncture enhances the production of endogenous NT-3 in damaged spinal cord tissues.
2
Increased local NT-3 production promotes the survival, migration, and maintenance of the grafted MN, which expressed NT-3 high-affinity TrkC.
3
The combination of MN implantation and EA application improved cortical motor-evoked potential relay and facilitated the locomotor performance of the paralyzed hindlimb compared with those of controls.

Research Summary

The study demonstrates that electroacupuncture (EA) as an adjuvant therapy for TrkC-modified mesenchymal stem cell-derived MN increases the local production of NT-3. This increase in NT-3 accelerates neural network reconstruction in the injured spinal cord. Ultimately electroacupuncture helps in the restoration of spinal cord function following SCI.

Practical Implications

Enhanced Neural Network Reconstruction

Electroacupuncture, combined with stem cell therapy, offers a promising approach for promoting neural network reconstruction in spinal cord injuries.

Improved Motor Function Recovery

The combined treatment leads to improved motor function of paralyzed hindlimbs, indicating potential for functional restoration.

NT-3 as a Therapeutic Target

NT-3 plays a crucial role in the observed benefits, highlighting its potential as a therapeutic target for spinal cord injury treatment.

Study Limitations

1
The study was conducted on a rat model, and results may not directly translate to humans.
2
The long-term effects of the combined treatment were not assessed.
3
The specific mechanisms by which electroacupuncture increases NT-3 levels require further investigation.

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