Electromagnetic Cellularized Patch with Wirelessly Electrical Stimulation for Promoting Neuronal Differentiation and Spinal Cord Injury Repair

Stem cell therapy shows promise for spinal cord injury (SCI) treatment, but its use is limited by the low degree of neural differentiation. The researchers propose an electromagnetic cellularized patch composed of graphite nanosheets and neural stem cells (NSCs). When implanted in the subarachnoid region of the injured spinal cord, the electromagnetic cellularized patch improves the behavioral performance of the hind limbs and the repair of spinal cord tissue in SCI mice.

• 1
  The generated pulsed electrical signals promote the differentiation of NSCs into functional mature neurons and increase the proportion of neurons from 12.5% to 33.7%.
• 2
  The strength and frequency of the induced voltage can be controlled by adjusting the rotation speed of the magnetic field.
• 3
  This electromagnetic cellularized patch holds great promise for the remote treatment of SCI and other diseases of the central and peripheral nervous systems.