Electrophysiology Methods for Assessing of Neurodegenerative and Post-Traumatic Processes as Applied to Translational Research

Electrophysiological studies are reliable for assessing brain and spinal cord function, neurodegeneration, and therapy effectiveness. They can also diagnose, predict outcomes, and evaluate rehabilitation programs in clinical and preclinical settings. This review examines electrophysiological assessments in neurodegenerative and post-traumatic processes and their translation from animal models to humans, contributing to understanding these methods. Surface EMG and EEG data are non-invasive and relatively inexpensive, making them advantageous for assessing neurological diseases and predicting functional outcomes.

• 1
  EEG data in animals and humans are practically comparable under normal conditions, with some differences related to anatomical features and behavioral patterns.
• 2
  EMG techniques and curve types do not differ significantly between humans and animals, and decreased amplitudes of electrophysiological indices during peripheral nerve injury are common.
• 3
  In Parkinson's disease models, an increase in high-frequency bands on the EEG is characteristic, unlike humans; at the same time, a decrease in the indicators of slow-wave rhythms is preserved in both animals and humans.