Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

Alopecia, or hair loss, is a common dermatological issue often linked to inflammation, infection, and immune system problems. Current treatments have limitations, so new options are needed. This study explores using exosomes from adipose-derived stem cells (ADSC-Exos) as a potential treatment. ADSC-Exos were tested on dermal papilla cells (DPCs), which are important for hair follicle growth, and on mice with induced hair loss. The study examined how ADSC-Exos affect DPC proliferation, migration, and apoptosis (cell death), as well as hair regrowth in mice. The researchers found that ADSC-Exos promoted DPC growth and movement while reducing cell death. In mice, ADSC-Exos treatment led to better hair growth. The study suggests that ADSC-Exos regulate certain pathways involved in hair growth, making them a possible therapy for immune-related alopecia.

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  ADSC-Exos significantly promoted DPC proliferation and migration while also reducing apoptosis in vitro.
• 2
  ADSC-Exos-treated mice had better hair growth, more hair follicles, and thicker dermis compared to the control group in vivo.
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  RNA sequencing revealed that the miR-22 and TNF-α signaling pathways were markedly downregulated in DPCs after ADSC-Exos treatment, while the Wnt/β-catenin signaling pathway was activated.