Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report

BMC Pediatrics, 2018 · DOI: https://doi.org/10.1186/s12887-018-1070-6 · Published: March 26, 2018

Simple Explanation

Germ cell tumors (GCTs) in children are rare, and mediastinal GCTs can be difficult to detect due to nonspecific symptoms. This case report describes a 7-year-old boy with a GCT in the posterior mediastinum that caused spinal cord compression, leading to leg weakness. The patient was treated with emergency surgery, steroid therapy, and chemotherapy and is now undergoing rehabilitation with no signs of recurrence.

Study Duration

3 years

Participants

7-year-old boy

Evidence Level

Case report

Key Findings

1
The patient presented with progressive back pain, leg weakness, and was found to have a large mass in the posterior mediastinum compressing the spinal cord.
2
Emergency surgery and steroid therapy were used to prevent further spinal cord injury, followed by cisplatin-based chemotherapy.
3
After treatment, the tumor decreased significantly, and the patient recovered some lower extremity strength and is undergoing rehabilitation.

Research Summary

This case report highlights a rare presentation of a germ cell tumor (GCT) in the posterior mediastinum of a child, leading to spinal cord compression and paraparesis. The child was treated with a combination of emergency surgical decompression, high-dose steroid therapy, and cisplatin-based chemotherapy. The patient showed a positive response to treatment and is undergoing rehabilitation, emphasizing the importance of prompt diagnosis and multidisciplinary management in such cases.

Practical Implications

Early Diagnosis

Prompt recognition of spinal cord compression symptoms is crucial for timely intervention.

Multidisciplinary Approach

Effective management requires a coordinated effort from surgeons, oncologists, and rehabilitation specialists.

Treatment Strategy

Emergency decompression surgery combined with steroid therapy and chemotherapy can lead to favorable outcomes in pediatric GCT cases with spinal cord compression.

Study Limitations

1
Single case report limits generalizability
2
Limited tissue specimen obtained during emergency surgery
3
Follow-up period of 3 years may not be sufficient to assess long-term outcomes

Your Feedback

Was this summary helpful?

Back to Oncology