Filling the Gap: Neural Stem Cells as A Promising Therapy for Spinal Cord Injury

Spinal cord injury (SCI) is a devastating condition with limited effective treatments. Neural stem cells (NSCs) offer a potential therapeutic approach by regenerating damaged tissue. NSCs can differentiate into various neural cell types, provide neurotrophic support, and restore synaptic connectivity, making them particularly relevant for SCI treatment. Clinical trials have been launched to assess the safety and efficacy of NSC-based therapies in SCI patients, marking a significant step towards translating experimental findings into clinical applications.

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  NSCs have shown regenerative effects in SCI models by providing neurotrophic support and restoring synaptic connectivity.
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  NSCs can differentiate into neurons, oligodendrocytes, and astrocytes, promoting axonal regrowth, remyelination, and regeneration of the corticospinal tract.
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  NSC grafts have demonstrated the capacity to fill lesion cavities, reduce glial scar formation, and survive transplantation.