Focal arm weakness following intradetrusor botulinum toxin administration in spinal cord injury: Report of two cases

This report describes two cases where patients with spinal cord injuries experienced weakness in their arms after receiving botulinum toxin injections in their bladders. The arm weakness was temporary, lasting about three months, while the bladder treatment effects lasted longer. The arm weakness mainly affected the shoulder and triceps muscles. This type of localized weakness hadn't been reported before as a side effect of this bladder treatment. The researchers suggest possible reasons for this side effect, including the toxin spreading or affecting nerves in unexpected ways.

• 1
  Two tetraplegic patients experienced proximal arm weakness following intradetrusor onabotulinumtoxinA administration.
• 2
  The arm weakness lasted approximately three months, while the bladder effects persisted for over six months.
• 3
  In one case, the proximal arm weakness recurred after repeat intradetrusor botulinum toxin injection.