Glycine and N-Acetylcysteine (GlyNAC) Combined with Body Weight Support Treadmill Training Improved Spinal Cord and Skeletal Muscle Structure and Function in Rats with Spinal Cord Injury

This study investigates the effects of GlyNAC (glycine and N-acetylcysteine) and body weight support treadmill training (BWSTT) on rats with spinal cord injury (SCI). It explores whether this combination can protect nerves, improve motor function, and prevent muscle atrophy. The research found that GlyNAC alone improved motor function in SCI rats. Combining GlyNAC with BWSTT was even more effective in improving voluntary motor function. The study also showed that GlyNAC improves the structure and function of skeletal muscles in rats with SCI, delaying muscle atrophy. This suggests that GlyNAC, especially when combined with BWSTT, could be a beneficial treatment for SCI.

• 1
  GlyNAC alone improved motor function, as indicated by BBB scores, gait symmetry, and open field test results.
• 2
  GlyNAC combined with BWSTT was more effective than either treatment alone at improving voluntary motor function in injured rats.
• 3
  GlyNAC improved the structure and function of skeletal muscle and delayed atrophy in rats with SCI, as shown by myofiber cross-sectional area, hindlimb grip strength, and acetylcholinesterase immunostaining analysis.