Identification of hub genes related to the innate immune response activated during spinal cord injury

Spinal cord injury (SCI) often leads to sensory and motor dysfunction, complicated by local inflammation and glial scar formation. This study identifies key genes (hub genes) involved in the immune response after SCI, which could be targets for new therapies. The research analyzes gene expression changes over time in mice with SCI and validates these findings using qPCR and single-cell sequencing data.

• 1
  Nine hub genes (Ccl2, Stat3, Mapk14, Stat1, Tlr2, Cxcl10, Myd88, Itgam, and Mapk8) were identified as key players in the innate immune response after SCI.
• 2
  The expression patterns of these hub genes vary over time after SCI, suggesting different roles at different stages of injury and repair.
• 3
  Several hub genes (ITGAM, MAPK14, MYD88, STAT3, TLR2) are also highly expressed in the blood of human SCI patients, indicating their potential as biomarkers or therapeutic targets.