Identification of key pathways and RNAs associated with skeletal muscle atrophy after spinal cord injury

This study investigates the molecular mechanisms behind muscle loss after spinal cord injury (SCI) by analyzing gene expression data. The study identifies key genes and pathways that are altered in skeletal muscle after SCI, using bioinformatics techniques to analyze a dataset of gene expression in muscle biopsies from SCI patients. The findings suggest potential therapeutic targets for preventing or treating muscle atrophy in individuals with SCI, focusing on specific genes, non-coding RNAs, and signaling pathways.

• 1
  UBE2D1, JUN, and FBXO32 are identified as key genes related to skeletal muscle atrophy after SCI, suggesting their potential involvement in the progression of muscle wasting.
• 2
  The MAPK and FoxO signaling pathways are significantly enriched, indicating their roles in inducing skeletal muscle inflammation, apoptosis, autophagy, and atrophy following SCI.
• 3
  The RP11-253E3.3-hsa-miR-1207-5p-FOXO3 axis is proposed as a promising therapeutic target for skeletal muscle atrophy after SCI, suggesting a potential regulatory pathway for intervention.