Imaging and clinical properties of inflammatory demyelinating pseudotumor in the spinal cord

Inflammatory demyelinating pseudotumors are rare lesions in the spinal cord that can mimic intramedullary tumors like gliomas on imaging. This study reviewed 36 cases to better understand their characteristics and avoid misdiagnosis. The study found that these pseudotumors often present with acute or subacute onset and sensorimotor disorders. A key MRI finding is the 'open-loop sign,' and pathological examination reveals inflammatory cell infiltration and demyelination. These lesions can be misdiagnosed as gliomas, leading to unnecessary surgery. Recognizing the imaging and pathological properties of inflammatory demyelinating pseudotumors is crucial for accurate diagnosis and treatment.

• 1
  Most patients experienced acute or subacute onset, exhibiting sensorimotor disorders.
• 2
  Magnetic resonance imaging revealed edema and space-occupying lesions with a predominant feature of non-closed rosette-like reinforcement (open-loop sign).
• 3
  Pathological examination showed perivascular cuffing of predominantly dense lymphocytes, and demyelination was observed in six of the misdiagnosed cases.