Immunoregulation of Glia after spinal cord injury: a bibliometric analysis

Frontiers in Immunology, 2024 · DOI: 10.3389/fimmu.2024.1402349 · Published: June 13, 2024

Simple Explanation

This study explores research trends related to how glial cells regulate the immune response after spinal cord injury (SCI). It uses a method called bibliometric analysis to look at publications on this topic. The study looks at which countries, institutions, and authors are most involved in this research area. It also identifies common keywords and topics that are currently of interest. The goal is to provide a better understanding of the direction of research in glial cell immunoregulation after SCI, which could help in finding new ways to treat SCI.

Study Duration

20 Years

Participants

Not specified

Evidence Level

Systematic Review

Key Findings

1
The United States is the most active country in this research area, with the most publications and international collaborations.
2
Nantong University has rapidly increased its research output in glial cell immunomodulation after SCI.
3
Keywords such as “microglia,” “activation,” “macrophages,” “astrocytes,” and “neuroinﬂammation” are currently hot topics in this field and are expected to remain a focus of future research.

Research Summary

This study provides a bibliometric analysis of glial cell immunoregulation after spinal cord injury (SCI) from 2004 to 2023, identifying global research trends and hotspots. The analysis reveals that the United States is a leading country in this field, and keywords like microglia and astrocytes are central to current research. The findings suggest that understanding glial cell interactions may be crucial for promoting nerve regeneration and repair after SCI, highlighting potential therapeutic targets.

Practical Implications

Targeted Therapies

The study identifies glial cells, particularly microglia and astrocytes, as potential therapeutic targets for SCI, suggesting the development of immunomodulatory drugs.

International Collaboration

Encourages greater cooperation and communication between countries and institutions to accelerate the development of treatments for SCI.

Research Focus

Highlights the importance of understanding the interactions between microglia, astrocytes, and other glial cells to promote neurological repair after SCI.

Study Limitations

1
Only publications from the Web of Science Core Collection were included.
2
There might be inconsistencies in the names of some institutions or journals at different times.
3
The analysis did not include publications outside of 2004-2023.

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