Infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and hematopoietic stem cells in post-traumatic paraplegia offers a viable therapeutic approach

Advanced Biomedical Research, 2016 · DOI: 10.4103/2277-9175.178792 · Published: January 1, 2016

Spinal Cord Injury Regenerative Medicine & Stem Cells

Simple Explanation

The study explores a new approach to treat spinal cord injuries (SCI) using stem cells. Current treatments for SCI have limited success in restoring lost function. The researchers used a combination of two types of stem cells: neuronal stem cells derived from the patient's own fat tissue and hematopoietic stem cells from bone marrow. The stem cells were infused into the cerebrospinal fluid (CSF) of patients with post-traumatic paraplegia. The goal was to see if this approach could improve motor and sensory functions.

Study Duration

4 Years

Participants

10 paraplegics

Evidence Level

Not specified

Key Findings

1
The co-infusion of N-Ad-MSC and HSC in CSF is a safe and viable therapeutic approach for SCIs.
2
Variable and sustained improvement in Hauser’s index and ASIA score was noted in all patients over a mean follow‑up of 2.95 years.
3
ASIA score improved from A to B in 6, A to C in 3, and A to D in 1 patient.

Research Summary

This study investigated the safety and efficacy of co-infusing autologous adipose tissue-derived mesenchymal stem cells (N-Ad-MSC) and hematopoietic stem cells (HSCs) in patients with post-traumatic paraplegia. Ten patients were enrolled, and the stem cells were infused into the cerebrospinal fluid below the injury site. The study found no untoward effects of the stem cell therapy. Patients showed variable and sustained improvements in Hauser’s index and ASIA score over a mean follow-up of 2.95 years, suggesting that co-infusion of N-Ad-MSC and HSC in CSF is a safe and viable therapeutic approach for SCIs.

Practical Implications

Therapeutic Potential

The co-infusion of N-Ad-MSC and HSC in CSF presents a potential therapeutic approach for spinal cord injuries, offering hope for improved motor and sensory functions.

Safety and Viability

The study demonstrates the safety and viability of this stem cell therapy, paving the way for further research and clinical trials.

Future Research

The positive outcomes observed warrant further investigation into the mechanisms of action and optimization of this therapeutic approach.

Infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and hematopoietic stem cells in post-traumatic paraplegia offers a viable therapeutic approach

Simple Explanation

Key Findings

Research Summary

Practical Implications

Therapeutic Potential

Safety and Viability

Future Research

Study Limitations

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Infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and hematopoietic stem cells in post-traumatic paraplegia offers a viable therapeutic approach

Simple Explanation

Key Findings

Research Summary

Practical Implications

Therapeutic Potential

Safety and Viability

Future Research

Study Limitations

Your Feedback

Was this summary helpful?