Inhibition of phospholipase D promotes neurological function recovery and reduces neuroinflammation after spinal cord injury in mice

Spinal cord injury (SCI) often leads to lasting neurological issues and creates a significant financial strain. Current treatments have limited success, leading researchers to explore ways to lessen the effects of secondary injuries that worsen SCI. The study investigates the role of Phospholipase D (PLD), a molecule involved in inflammation. By using a PLD inhibitor (FIPI) in mice with SCI, the researchers aimed to observe if reducing PLD activity could aid in recovery. The findings suggest that inhibiting PLD helps in improving motor skills, reducing tissue damage, and decreasing inflammation in mice with SCI. This indicates PLD could be a target for new SCI treatments.

• 1
  PLD expression increases after SCI, suggesting its involvement in secondary injury processes post-SCI.
• 2
  Inhibition of PLD with FIPI significantly improves locomotor activity in mice after SCI, as shown by BMS scores and open-field tests.
• 3
  FIPI treatment protects spinal cord tissue in SCI mice by reducing tissue atrophy and preserving nerve conduction structures.