Integrated Neuroregenerative Techniques for Plasticity of the Injured Spinal Cord

This perspective article reviews current interventions for spinal cord injury (SCI) treatment, focusing on rehabilitation phases. It emphasizes a neuroplasticity-based approach to promote functional recovery and improve life quality after SCI. The article highlights the integration of biomolecular approaches, neuromodulation, and sensorimotor rehabilitation to optimize interventions and reduce reliance on medications that may not reverse the recovery process. It explores the pathophysiology of SCI, the timing of functional recovery, and the potential of combining biomolecular advancements with various interventions to enhance quality of life after SCI.

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  Biomolecular approaches alone have modest outcomes in SCI treatment.
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  Nanotechnology can facilitate drug transport and overcome biological barriers, improving pharmacological treatment of SCI.
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  Hydrogels offer mechanical support, promote cell migration, and facilitate long-term drug release, potentially improving QOL after SCI.