ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation

Journal of Orthopaedic Translation, 2025 · DOI: https://doi.org/10.1016/j.jot.2025.01.003 · Published: January 8, 2025

Simple Explanation

Spinal cord injury (SCI) often leads to nerve cell death and inflammation, hindering recovery. This study explores how ISRIB, a drug known to reduce inflammation in brain injuries, might help in SCI. The researchers used models to mimic SCI conditions and tested ISRIB's effects on nerve cells and immune cells. They found that ISRIB reduced nerve cell death and modulated inflammation by affecting specific signaling pathways. In mice with SCI, ISRIB treatment promoted the recovery of motor and sensory functions. This suggests ISRIB could be a potential therapeutic option for SCI.

Study Duration

28 days

Participants

C57BL/6 mice (6–8 weeks, female)

Evidence Level

Not specified

Key Findings

1
ISRIB suppresses neuron death and neuroinflammation following SCI.
2
ISRIB regulates neuron apoptosis through the P53 signaling pathway.
3
ISRIB modulates neuroinflammation by the JAK2/STAT3 signaling pathway.

Research Summary

This study investigates the role of ISRIB in promoting neural functional recovery following SCI and elucidates its underlying molecular mechanisms. The findings revealed that ISRIB suppressed apoptosis via the P53 signaling pathway and modulated neuroinflammation following SCI through the JAK2/STAT3 signaling pathway. In vivo experiments further revealed that intraperitoneal injection of ISRIB promoted motor and sensory function recovery in mice with SCI, supporting the potential of ISRIB as a therapeutic option for SCI.

Practical Implications

Therapeutic Potential for SCI

ISRIB may serve as a potential therapeutic strategy for the repair of SCI.

Dual Mechanisms of Action

Unlike other drugs that target SCI through a single pathway, ISRIB demonstrates dual mechanisms of action by both reducing neuronal apoptosis and modulating neuroinflammation.

Clinical Application

ISRIB may have clinical applications in regulating neuroinflammation following SCI.

Study Limitations

1
Whether ISRIB could be used in clinic need to do some large animal experiment.
2
The direct regulatory role of ISRIB on key proteins within these pathways remains a focus of our future research.
3
Even no approach has been found to make spinal cord injured patient complete recovery

Your Feedback

Was this summary helpful?

Back to Spinal Cord Injury