Evidence-Based Complementary and Alternative Medicine, 2020 · DOI: https://doi.org/10.1155/2020/9542359 · Published: November 28, 2020
This study investigates how Jisuikang (JSK), a traditional Chinese medicine, helps in spinal cord injury (SCI) recovery in rats. It focuses on JSK's impact on nerve regeneration by looking at the NgR/RhoA/ROCK signaling pathway. The research showed that JSK improved motor function in rats with SCI, protected the structure of nerve cells, and lowered the rate of nerve cell death. It suggests JSK's potential as a treatment for nerve damage. JSK appears to work by blocking the Nogo receptor (NgR) and the NgR/RhoA/ROCK pathway, which normally inhibits nerve regeneration. By inhibiting this pathway, JSK creates a more favorable environment for nerve repair.
JSK could be further explored as a therapeutic agent for spinal cord injury due to its neuroprotective and regenerative properties.
The NgR/RhoA/ROCK pathway is a viable target for SCI treatment strategies, and JSK provides a means to modulate this pathway.
Further research is warranted to translate these findings into clinical applications for SCI patients, potentially improving their motor function and quality of life.