Linarin inhibits microglia activation-mediated neuroinflammation and neuronal apoptosis in mouse spinal cord injury by inhibiting the TLR4/NF-κB pathway

Spinal cord injury (SCI) is a debilitating condition where secondary damage, including inflammation, significantly worsens the initial injury. Current treatments are limited, creating a need for effective medications. Linarin (LIN), a natural compound, shows promise due to its anti-inflammatory and neuroprotective properties. This study investigates LIN's potential to protect against SCI-induced inflammation and neuronal damage in mice. The research uses a mouse model of SCI and cell cultures to examine how LIN affects inflammation, nerve cell survival, and motor function recovery. The findings suggest LIN could be a valuable therapeutic agent for SCI.

• 1
  Linarin treatment significantly improved motor function in SCI mice, as evidenced by higher BMS scores, better performance in the inclined plane test, and improved footprint analysis scores.
• 2
  Linarin reduced spinal cord tissue damage and increased myelination in SCI mice, indicating a protective effect on the spinal cord structure.
• 3
  Linarin inhibited microglia activation and suppressed the release of pro-inflammatory factors (iNOS, COX-2, TNF-α, IL-6, and IL-1β) both in vivo and in vitro, suggesting a mechanism for its neuroprotective effects.