Mechanism of spinal cord injury regeneration and the effect of human neural stem cells-secretome treatment in rat model

This study investigates how spinal cord injuries (SCI) might regenerate and whether a treatment using secretomes from human neural stem cells (HNSCs) can help. The study uses a rat model of SCI to test the effects of HNSCs-secretome on various factors related to inflammation, nerve growth, and recovery of movement. The findings suggest that HNSCs-secretome could be a promising treatment for SCI, improving motor function and promoting nerve regeneration through a specific sequence of biological events.

• 1
  HNSCs-secretome significantly improved locomotor recovery, as measured by BBB scores, in rats with SCI.
• 2
  The treatment decreased the size of spinal cord lesions and reduced pro-inflammatory markers (NF-κB, MMP9, TNF-α).
• 3
  HNSCs-secretome increased neurogenesis (nestin, BDNF, GDNF), neuroangiogenesis (VEGF), and anti-apoptotic (Bcl-2) markers.