Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study

This study investigates whether midodrine, a medication used to treat low blood pressure, can help men with spinal cord injuries (SCI) who cannot ejaculate to achieve antegrade ejaculation. The study involved a double-blind, randomized, placebo-controlled trial, where some men received midodrine and others a placebo, followed by penile vibratory stimulation (PVS). The results showed that midodrine, combined with PVS, did not significantly improve the rate of antegrade ejaculation compared to the placebo group. The small sample size limits definitive conclusions.

• 1
  Treatment of anejaculation after SCI with midodrine and PVS did not result in a better rate of antegrade ejaculation in 10 men than in 10 men treated with a placebo and PVS.
• 2
  Only one participant (10%) from the midodrine group reached ejaculation while two participants (20%) from the placebo group reached ejaculation.
• 3
  A significant average increase of 16.2 mm was observed in systolic BP for the group M 1 hour after taking midodrine (P < 0.001).