Minimally Invasive and Regenerative Therapeutics

Adv Mater, 2019 · DOI: 10.1002/adma.201804041 · Published: January 1, 2019

Surgery Biomedical Regenerative Medicine & Stem Cells

Simple Explanation

Minimally invasive therapeutics use cells, biomaterials, and biomolecules to regenerate tissues like bone, cartilage, heart, and neural tissues. Nanobiomaterials and bioelectronic devices allow tracking and stimulation of these therapeutics in the body. Minimally invasive delivery offers high yield, low risk, and reduced costs compared to traditional methods.

Study Duration

Not specified

Participants

Not specified

Evidence Level

Not specified

Key Findings

1
Needles have been utilized to deliver cell-laden biomaterials into the body.
2
Nanoparticles combined with therapeutics can be guided to the target site using magnetic forces.
3
Combinatorial therapies, using cells, biomolecules, and biomaterials together, show promise in tissue regeneration.

Research Summary

Advances in biomaterial synthesis, stem cell biology, bioimaging, microsurgery, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeutics can be delivered in a minimally invasive way to regenerate different tissues in the body, such as bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues. Although some clinical trials have been done using MIRET, it is hoped that such therapeutics find wider applications to treat patients.

Practical Implications

Enhanced Tissue Regeneration

MIRET offers a less traumatic approach to delivering regenerative therapeutics, leading to faster recovery and reduced complications.

Targeted Drug Delivery

Nanoparticles and microdevices allow for precise delivery of drugs and growth factors to specific sites in the body.

Personalized Medicine

3D printing and smart scaffolds can be used to create custom-designed implants and therapies tailored to individual patients.

Study Limitations

1
Challenges in large-scale production and preservation of regenerative therapeutics.
2
Need for more extensive and large-scale clinical trials to prove safety and efficacy.
3
Technical challenges in navigating complex anatomical routes with catheters and microrobots.

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