Multi‑omics uncovers immune‑modulatory molecules in plasma contributing to resistance exercise‑ameliorated locomotor disability after incomplete spinal cord injury

This research investigates how resistance exercise improves recovery in people with spinal cord injuries. The study looks at molecular changes in the blood and immune cells following resistance exercise. The study uses both human trials and mouse models to understand these changes. The findings suggest that resistance exercise leads to the release of specific molecules in the blood that can directly protect nerve cells and improve motor function after a spinal cord injury.

• 1
  Resistance exercise, especially isotonic exercise, improves muscle strength, walking ability, and balance in individuals with incomplete SCI.
• 2
  Resistance exercise modulates the complement pathway and humoral immune response, which are crucial for locomotor function recovery.
• 3
  Exercise plasma contains factors that can directly protect nerve cells, reduce demyelination, and inhibit neuronal apoptosis after SCI in mice.