Nerve transfer for restoration of lower motor neuron–lesioned bladder and urethra function: establishment of a canine model and interim pilot study results

This study investigates nerve transfer as a method to restore bladder function in canines with lower motor neuron lesions. The researchers simulated spinal cord or cauda equina injuries in dogs to observe if nerve transfers could restore bladder and sphincter function. The study involved transecting sacral roots and hypogastric nerves in some animals, with additional transection of L7 dorsal roots in others. After a period of decentralization, nerve transfers were performed to reconnect nerves and restore function. The findings suggest that nerve transfer can restore bladder sensation and motor function even after a significant period of decentralization, offering a potential surgical treatment for patients with lower motor neuron lesion-induced bladder dysfunction.

• 1
  Transection of L7 dorsal roots was necessary for significant reduction of squat-and-void postures after sacral root transection.
• 2
  Nerve transfers restored squat-and-void postures in animals 4–6 months after reinnervation.
• 3
  Electrical stimulation of transferred nerves induced bladder contractions and anal sphincter contractions.