Neuroplasticity, limbic neuroblastosis and neuro-regenerative disorders

Neuroplasticity is the brain's ability to change and adapt throughout life in response to experience, environmental stimuli, and disease. These changes occur at the cellular level, involving biochemical pathways and synaptic remodeling, which facilitates neurological rehabilitation and helps maintain brain balance. Adult neurogenesis, the generation of new neurons in the adult brain, is a key aspect of neuroplasticity. It occurs in the hippocampus and subventricular zone (SVZ) and has been linked to cognitive functions and neural regeneration in response to brain diseases and injuries. Neuroblasts, immature neurons, play a critical role in neuroplasticity and adult neurogenesis. They are generated in the limbic system and basal ganglia, and their characteristics and functions vary among mammals, influencing sensorimotor interfaces and regenerative neuroplasticity.

• 1
  Adult neurogenesis occurs not only in the hippocampus and SVZ but also in other brain regions like the cortex, amygdala, hypothalamus, and striatum, which are associated with the limbic system and basal ganglia.
• 2
  Neuroblasts are heterogeneous with multipotential capacity, robust migratory potential, and are modulated by sensorimotor inputs, representing a limbic-motor interface.
• 3
  Reactive neuroblastosis, a rapid non-malignant cell division followed by apoptosis, is observed in response to early pathogenesis of neurological disorders, including stroke, epilepsy, and Alzheimer's disease.