Neurorehabil Neural Repair, 2008 · DOI: 10.1177/1545968307308550 · Published: March 1, 2008
The myelin protein Nogo inhibits axon regeneration by binding to its receptor (NgR) on axons. Blocking this receptor with a specific antagonist (NEP1-40) has shown promise in promoting axon growth and functional recovery after spinal cord injury. This study examines the effects of NEP1-40 on recovery and repair after a lateral funiculotomy, a specific type of spinal cord injury that affects the rubrospinal tract (RST), which is important for motor control. Rats with a lateral funiculotomy received either NEP1-40 or a control substance for four weeks. The researchers then assessed their motor and sensory functions, as well as examined their spinal cords to observe axonal growth and changes.
NgR blockade could be a therapeutic strategy to promote recovery after spinal cord injury.
Combining NgR blockade with other treatments, such as neurotrophic factors or cell transplants, may enhance recovery.
Different types of axons may respond differently to NgR blockade, suggesting the need for tailored therapeutic approaches.