Non-invasive Neuromodulation of Spinal Cord Restores Lower Urinary Tract Function After Paralysis

Frontiers in Neuroscience, 2018 · DOI: 10.3389/fnins.2018.00432 · Published: June 29, 2018

Simple Explanation

This study introduces Transcutaneous Electrical Spinal Stimulation for LUT functional Augmentation (TESSLA), a non-invasive method to improve bladder and urethral function in SCI patients. TESSLA may help transform spinal networks to a more functional state, potentially improving the quality of life for SCI patients. The key advantages of TESSLA include its non-invasive nature and adaptability to individual subjects.

Study Duration

Not specified

Participants

7 individuals with SCI

Evidence Level

Not specified

Key Findings

1
TESSLA reduced detrusor overactivity (DO), which is a condition where the bladder contracts involuntarily during urine storage.
2
TESSLA decreased detrusor-sphincter dyssynergia (DSD), a condition where the bladder and urethral sphincter do not coordinate properly.
3
TESSLA increased bladder capacity and enabled voiding, addressing the inability to urinate on command.

Research Summary

This study demonstrates that TESSLA, a non-invasive neuromodulatory technique, can reengage the spinal circuits active in LUT function and normalize bladder and urethral sphincter function in individuals with SCI. TESSLA reduced DO, decreased DSD, increased bladder capacity and enabled voiding, suggesting it can transform intrinsic spinal networks to a more physiological state. TESSLA offers advantages over current therapies, being non-invasive and modulating spinal networks with specificity, potentially leading to plastic changes in the circuitry controlling bladder function.

Practical Implications

Improved Quality of Life

Restoring LUT function improves quality of life and reduces the risk of complications.

Reduced Healthcare Costs

Effective LUT management can lower healthcare costs associated with incontinence, kidney injury, and UTIs.

Non-Invasive Alternative

TESSLA offers a non-invasive alternative to current invasive treatments for LUT dysfunction.

Study Limitations

1
Further studies are needed to determine the long-term impact of TESSLA and training on LUT function.
2
The sample size of seven participants is relatively small, limiting the generalizability of the findings.
3
The study did not assess other pelvic autonomic functions such as bowel and sexual function.

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