Pellegrini-Stieda Disease in a Severely Injured Patient with Spinal Cord Injury

Pellegrini-Stieda disease (PSD) involves ossification or calcification on the medial side of the knee, typically at the medial collateral ligament's proximal attachment. The disease often stems from a traumatic injury, but can also arise from micro-repetitive trauma during rehabilitation or therapeutic manipulations. Most individuals with PSD are asymptomatic, but some may experience pain, local swelling, and limited range of motion in the affected knee.

• 1
  This case report highlights an unusual presentation of Pellegrini-Stieda disease in a patient with a spinal cord injury but without recent knee trauma.
• 2
  The literature review identified only a few cases of PSD following neurological injuries, suggesting a potential link between these conditions.
• 3
  Factors such as tissue hypoxia, hypercalcemia, altered sympathetic nerve activity, prolonged immobilization, and mobilization patterns may contribute to ectopic bone formation in PSD related to neurological injuries.