Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders

Frontiers in Bioengineering and Biotechnology, 2021 · DOI: 10.3389/fbioe.2021.724158 · Published: October 12, 2021

Simple Explanation

Biomaterials play a significant role in nanotechnology, leading to advancements in biomedical sciences. They show promise in drug delivery and regenerative therapies for neurological conditions. Hydrogels are flexible, porous, and mimic the extracellular matrix of the central nervous system, making them ideal for drug delivery and tissue regeneration. This review discusses the application of biomaterials and current advancements in treating common neurological disorders.

Study Duration

Not specified

Participants

Not specified

Evidence Level

Review Article

Key Findings

1
Self-assembling peptides and hydrogels are potential candidates for treating neurological conditions like Alzheimer’s, Parkinson’s, spinal cord injury, stroke, and tumors.
2
Hydrogels offer flexibility and porosity, mimicking the extracellular matrix of the CNS, making them suitable for drug delivery and tissue regeneration.
3
Stimuli-responsive nanomaterials enable non-invasive neuro-imaging, improving neurological disease diagnosis and treatment outcomes.

Research Summary

The central nervous system (CNS) has limited regeneration capacity, posing challenges for treating neurological disorders, but cell-based therapies offer a potential solution by delivering regenerative molecules. Biomaterials, including hydrogels and self-assembling peptides, show promise in drug delivery and tissue regeneration for neurological conditions. Nanomaterials offer advantages like enhanced bioavailability, sustained drug release, and targeted delivery to damaged cells or lesion sites in neurological diseases.

Practical Implications

Drug Delivery Systems

Biomaterials can improve drug delivery across the blood-brain barrier, enhancing the effectiveness of treatments for neurological disorders.

Tissue Regeneration

Hydrogels and other biomaterials provide a scaffold for stem cells, promoting tissue regeneration in the CNS and aiding recovery from injuries or diseases.

Diagnostic Tools

Stimuli-responsive nanomaterials can be used for non-invasive neuro-imaging, allowing for early diagnosis and improved treatment outcomes for neurological diseases.

Study Limitations

1
Varied solubility of nanomaterials at different temperatures.
2
Potential toxicity of synthetic materials due to high surface area.
3
Unpredictable inflammation or oxidative stress triggered by biomaterial application.

Your Feedback

Was this summary helpful?

Back to Neurology