Regeneration in the spiny mouse, Acomys, a new mammalian model

The study focuses on the spiny mouse, Acomys, and its remarkable ability to regenerate various tissues and organs after injury. Compared to typical mammals like lab mice (Mus), Acomys exhibits superior regeneration in skin, ear, muscle, heart, spinal cord, and kidney. This enhanced regenerative capability is attributed to a blunted inflammatory response and unique biomechanical properties of Acomys tissues.

• 1
  Acomys can regenerate skin, including hair follicles, sebaceous glands, dermis, and muscle, without forming scars after excisional wounds or burns.
• 2
  Following ear punches, Acomys regenerates missing tissue, including cartilage, demonstrating epimorphic regeneration similar to salamander limb regeneration.
• 3
  Internal tissues, such as heart, kidney, muscle, and spinal cord, show reduced inflammation and improved regeneration in Acomys compared to Mus after injury.