Role of Autologous Platelet-Rich Fibrin in Chronic Non-healing Ulcers With Various Etiologies in a Tertiary Care Rehabilitation Centre: A Case Series

Cureus, 2024 · DOI: 10.7759/cureus.68709 · Published: September 5, 2024

Rehabilitation Dermatology Regenerative Medicine & Stem Cells

Simple Explanation

Chronic non-healing ulcers are wounds that don't heal in a reasonable time due to underlying health issues. Platelet-rich fibrin (PRF) from the patient's own blood was applied to these wounds to help them heal. The study found that PRF improved healing, reduced wound size, and enhanced the patients' ability to perform daily activities.

Study Duration

Maximum follow-up period was 10 weeks

Participants

Six patients with eight wounds of varying etiology

Evidence Level

Case Series

Key Findings

1
PRF treatment led to a maximum healing rate of 3.84% per day based on the PUSH score.
2
The maximum healing rate in terms of surface area reduction was 5.89% per day.
3
Patients showed an average improvement of 15.87% in their Functional Independence Measure (FIM) scores after PRF application.

Research Summary

This case series investigated the use of autologous platelet-rich fibrin (PRF) on chronic non-healing ulcers with various etiologies in a rehabilitation center. The results indicate that PRF is a safe and effective method for accelerating the healing of these ulcers and improving patients' quality of life and functional independence. The study concludes that PRF can be an adjunctive treatment for pressure injuries and suggests further research to confirm these findings.

Practical Implications

Accelerated Wound Healing

PRF offers a promising approach to accelerate the healing of chronic non-healing ulcers, potentially reducing the burden on patients and healthcare systems.

Improved Functional Independence

By promoting faster wound closure, PRF can help patients regain functional independence and improve their ability to perform activities of daily living.

Safe and Effective Treatment Option

PRF has proven to be a safe and effective method for treating chronic ulcers, with no reported adverse reactions in this study.

Role of Autologous Platelet-Rich Fibrin in Chronic Non-healing Ulcers With Various Etiologies in a Tertiary Care Rehabilitation Centre: A Case Series

Simple Explanation

Key Findings

Research Summary

Practical Implications

Accelerated Wound Healing

Improved Functional Independence

Safe and Effective Treatment Option

Study Limitations

Your Feedback

Was this summary helpful?

Role of Autologous Platelet-Rich Fibrin in Chronic Non-healing Ulcers With Various Etiologies in a Tertiary Care Rehabilitation Centre: A Case Series

Simple Explanation

Key Findings

Research Summary

Practical Implications

Accelerated Wound Healing

Improved Functional Independence

Safe and Effective Treatment Option

Study Limitations

Your Feedback

Was this summary helpful?