Role of glial 14-3-3 gamma protein in autoimmune demyelination

This study investigates the role of 14-3-3 gamma protein in glial cells during autoimmune demyelination, a process similar to what happens in multiple sclerosis (MS). The researchers found that 14-3-3 gamma is expressed in oligodendrocytes and astrocytes, and its expression increases in the spinal cord during the chronic phase of experimental autoimmune encephalomyelitis (EAE). Mice lacking 14-3-3 gamma experienced more severe EAE, with increased myelin damage and oligodendrocyte injury, suggesting that 14-3-3 gamma plays a protective role for oligodendrocytes in neuroinflammation.

• 1
  14-3-3 γ mRNA expression increases in the spinal cord during the late chronic phase of MOG-EAE.
• 2
  14-3-3 γ knockout mice subjected to MOG-EAE exhibit more severe disease compared to controls, particularly in the chronic phase.
• 3
  Histopathological analyses reveal enhanced myelin damage, oligodendrocyte injury, increased axonal injury, and gliosis in 14-3-3 γ knockout mice during chronic EAE.