Serum and cerebrospinal fluid tau protein level as biomarkers for evaluating acute spinal cord injury severity and motor function outcome

This study investigates the potential of tau protein as a biomarker for spinal cord injury (SCI) severity and motor function outcome. The researchers measured tau protein levels in serum and cerebrospinal fluid (CSF) of rats with varying degrees of SCI. They found a correlation between tau protein levels and the severity of SCI, suggesting its potential as a biomarker.

• 1
  Tau protein levels in serum and CSF increased rapidly after SCI, peaking at 12 hours.
• 2
  A positive linear correlation was found between tau protein levels and SCI severity.
• 3
  Tau protein levels at 12 hours were negatively correlated with locomotor rating scale scores at 28 days.