Short‑term effects of oxybutynin dosage in individuals with neurogenic bladder following spinal cord injury: A retrospective cohort study

This study aimed to understand how different doses of oxybutynin affect bladder pressure in people with neurogenic bladder caused by spinal cord injury. The researchers reviewed hospital records of patients with these conditions, looking at bladder pressure before and after oxybutynin treatment. The study found that a higher dose of oxybutynin was linked to a lower bladder pressure, suggesting the drug is effective for managing this condition.

• 1
  Each 1 mg increase in oxybutynin dosage was associated with a mean decrease of 0.9 cmH2O in detrusor pressure.
• 2
  In patients with indwelling catheters, a 1 mg dose of oxybutynin was associated with a mean decrease in detrusor pressure of 0.5 cmH2O.
• 3
  In patients using clean intermittent catheterization, a 1 mg dose of oxybutynin was associated with a mean decrease in detrusor pressure of 1.0 cmH2O.