Steroid inhibited Serpina3n expression which was positively correlated with the degrees of spinal cord injury

This study aimed to identify proteins linked to the severity of spinal cord injury (SCI) and subsequent neurological recovery. The researchers found that Serpina3n, a protein, was significantly increased in the spinal cord after injury, with higher levels indicating more severe damage. The study suggests that Serpina3n could serve as a biomarker for acute SCI, reflecting injury severity and predicting long-term motor function recovery.

• 1
  Serpina3n protein expression significantly increased in the injured spinal cord segment after SCI, with higher levels in severe SCI cases.
• 2
  Serum Serpina3n levels were significantly correlated with the severity of injury at 12 h, 24 h, and 3 days post-injury.
• 3
  Methylprednisolone treatment decreased serum Serpina3n levels in mice with SCI and improved neurological recovery.